Background. Psoriasis is an immune-mediated inflammatory chronic skin disease characterized by chronic inflammation in the\ndermis, parakeratosis, and excessive epidermal growth. MicroRNAs (miRNAs) are key regulators of immune responses.\nAlthough differential expression of miRNAs has been reported in certain inflammatory autoimmune diseases, their role in\npsoriasis has not been fully illuminated. Our aims were to confirm plasma miRNA expression signatures in psoriasis and to\nexamine their potential influence on psoriasis pathogenesis. Methods. A miRNome PCR array was used to analyse the plasma of\npsoriasis patients and healthy donors. We performed miRNA pathway enrichment and target gene network analyses on\npsoriasis plasma samples. Results. We found several specific plasma miRNA signatures relevant to psoriasis. The miRNAs\ntargeted pathways associated with psoriasis, such as the VEGF, MAPK, and WNT signaling pathways. Network analysis revealed\npivotal deregulated plasma miRNAs and their relevant target genes and pathways regulating psoriasis pathogenesis. Conclusions.\nThis study analysed the expression of plasma miRNAs and their target pathways, elucidating the pathogenesis of psoriasis; these\nresults may be used to design novel therapeutic strategies and to identify diagnostic biomarkers for psoriasis.
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